David Hangauer : rechercher sur Z-Library

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1

Non-additivity of Functional Group Contributions in Protein–Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

Bernhard Baum, Laveena Muley, Michael Smolinski, Andreas Heine, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2010

2

Prevention of noise-induced hearing loss with Src-PTK inhibitors

Kelly Carney Harris, Bohua Hu, David Hangauer, Donald Henderson

Journal:

Hearing Research

Année:

2005

Langue:

english

Fichier:

PDF, 365 KB

english, 2005

3

Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons

Christof Gerlach, Michael Smolinski, Holger Steuber, Christoph A. Sotriffer, Andreas Heine, David G. Hangauer, Gerhard Klebe

Journal:

Angewandte Chemie International Edition

Année:

2007

Langue:

english

Fichier:

PDF, 518 KB

english, 2007

4

More than a Simple Lipophilic Contact: A Detailed Thermodynamic Analysis of Nonbasic Residues in the S1 Pocket of Thrombin

Bernhard Baum, Menshawy Mohamed, Mohamed Zayed, Christof Gerlach, Andreas Heine, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 796 KB

english, 2009

5

Think Twice: Understanding the High Potency of Bis(phenyl)methane Inhibitors of Thrombin

Bernhard Baum, Laveena Muley, Andreas Heine, Michael Smolinski, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2009

6

Congeneric but Still Distinct: How Closely Related Trypsin Ligands Exhibit Different Thermodynamic and Structural Properties

Tobias Brandt, Nicole Holzmann, Laveena Muley, Maan Khayat, Christof Wegscheid-Gerlach, Bernhard Baum, Andreas Heine, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 2.44 MB

english, 2011

7

Enhancement of Hydrophobic Interactions and Hydrogen Bond Strength by Cooperativity: Synthesis, Modeling, and Molecular Dynamics Simulations of a Congeneric Series of Thrombin Inhibitors

Muley, Laveena, Baum, Bernhard, Smolinski, Michael, Freindorf, Marek, Heine, Andreas, Klebe, Gerhard, Hangauer, David G.

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2010

8

Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO – Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes

Nasief, Nader N., Tan, Hongwei, Kong, Jing, Hangauer, David

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2012

9

Dissecting the Hydrophobic Effect on the Molecular Level: The Role of Water, Enthalpy, and Entropy in Ligand Binding to Thermolysin

Biela, Adam, Nasief, Nader N., Betz, Michael, Heine, Andreas, Hangauer, David, Klebe, Gerhard

Journal:

Angewandte Chemie International Edition

Année:

2013

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2013

10

Influence of Neighboring Groups on the Thermodynamics of Hydrophobic Binding: An Added Complex Facet to the Hydrophobic Effect

Nasief, Nader N., Hangauer, David

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 2.47 MB

english, 2014

11

Additivity or cooperativity: Which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?

Nasief, Nader N., Hangauer, David

Journal:

European Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 3.77 MB

english, 2015

12

Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors

Said, Ahmed M., Hangauer, David G.

Journal:

European Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 2.85 MB

english, 2015

13

Ligand Binding Cooperativity: Bioisosteric Replacement of C=O With SO2 Among Thrombin Inhibitors

Said, Ahmed M., Hangauer, David G.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 923 KB

english, 2016

14

Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation

Nasief, Nader N., Said, Ahmed M., Hangauer, David

Journal:

European Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2016

15

Thermodynamisches Inhibitionsprofil eines Cyclopentyl- und eines Cyclohexylderivats gegenüber Thrombin: gleich, jedoch aus unterschiedlichem Grund

Christof Gerlach, Michael Smolinski, Holger Steuber, Christoph A. Sotriffer, Andreas Heine, David G. Hangauer, Gerhard Klebe

Journal:

Angewandte Chemie

Année:

2007

Langue:

german

Fichier:

PDF, 518 KB

german, 2007

16

Live-Cell Imaging of Cellular Proteins by a Strain-Promoted Azide–Alkyne Cycloaddition

Dr. Kimberly E. Beatty, Dr. John D. Fisk, Dr. Brian P. Smart, Ying Ying Lu, Dr. Janek Szychowski, Dr. Matthew J. Hangauer, Dr. Jeremy M. Baskin, Prof. Carolyn R. Bertozzi, Prof. David A. Tirrell

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 356 KB

english, 2010

17

ChemInform Abstract: The Design, Synthesis, and Activity of Non-ATP Competitive Inhibitors of pp60c-src Tyrosine Kinase. Part 2. Hydroxyindole Derivatives.

Karen L. Milkiewicz, Thomas H. Marsilje, Richard P. Woodworth Jr., Neil Bifulco Jr., Matthew J. Hangauer, David G. Hangauer

Journal:

Année:

2000

Fichier:

PDF, 33 KB

2000

18

Total synthesis of pseudoguaianes—I: Preparation of bicyclo[5.3.0]decane synthons for damsinic acid and helenanolides

Peter T. Lansbury, Algirdas K. Serelis, John E. Hengeveld, David G. Hangauer Jr.

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 835 KB

english, 1980

19

Total synthesis of erbstatin

David G Hangauer

Journal:

Tetrahedron Letters

Année:

1986

Langue:

english

Fichier:

PDF, 261 KB

english, 1986

20

A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors

David G. Hangauer Jr.

Journal:

Tetrahedron Letters

Année:

1981

Langue:

english

Fichier:

PDF, 176 KB

english, 1981

21

C-10 epimerization of hydroazulen-7-onesby vinylogus activation

Peter T. Lansbury, David G. Hangauer

Journal:

Tetrahedron Letters

Année:

1979

Langue:

english

Fichier:

PDF, 202 KB

english, 1979

22

The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase. Part 2: Hydroxyindole derivatives

Karen L Milkiewicz, Thomas H Marsilje, Richard P Woodworth Jr., Neil Bifulco Jr., Matthew J Hangauer, David G Hangauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 131 KB

english, 2000

23

The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase.Part 1: Hydroxynaphthalene derivatives

Thomas H Marsilje, Karen L Milkiewicz, David G Hangauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 131 KB

english, 2000

24

Expression of Src and FAK in Hepatocellular Carcinoma and the Effect of Src Inhibitors on Hepatocellular Carcinoma In

Grace M. Lau, Gillian M. Lau, Guo-Liang Yu, Irwin H. Gelman, Alan Gutowski, David Hangauer, Jane W. S. Fang

Journal:

Digestive Diseases and Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 507 KB

english, 2009

25

Privileged scaffolds for blocking protein–protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX–PBX/DNA

Tao Ji, Madison Lee, Steven C. Pruitt, David G. Hangauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 301 KB

english, 2004

26

The design, synthesis and activity of pentapeptide pp60c-src inhibitors containing L-phosphotyrosine mimics

JACK H. LAI, THOMAS H. MARSILJE, SUN CHOI, SHRIKUMAR A. NAIR, DAVID G. HANGAUER

Journal:

Chemical Biology & Drug Design

Année:

1998

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1998

27

KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer

Muralidharan Anbalagan, Latonya Carrier, Seth Glodowski, David Hangauer, Bin Shan, Brian G. Rowan

Journal:

Breast Cancer Research and Treatment

Année:

2012

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2012

28

Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities

Asal Fallah-Tafti, Alireza Foroumadi, Rakesh Tiwari, Amir Nasrolahi Shirazi, David G. Hangauer, Yahao Bu, Tahmineh Akbarzadeh, Keykavous Parang, Abbas Shafiee

Journal:

European Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 453 KB

english, 2011

29

Tetrapeptide tyrosine kinase inhibitors : Enantioselective synthesis of p-hydroxymethyl-l-phenylalanine, incorporation into a tetrapeptide, and subsequent elaboration into p-(R,S-hydroxyphosphonomethyl)-l-phenylalanine

MOON H. KIM, JACK H. LAI, DAVID G. HANGAUER

Journal:

Chemical Biology & Drug Design

Année:

1994

Langue:

english

Fichier:

PDF, 853 KB

english, 1994

30

Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors

Eric C. Bielefeld, David Hangauer, Donald Henderson

Journal:

Neuroscience Research

Année:

2011

Langue:

english

Fichier:

PDF, 741 KB

english, 2011

31

Synthesis of a Vicinal Tricarbonyl Amide Derivative of l -Phenylalanine

Lai, Jack H., Pham, Ha, Hangauer, David G.

Journal:

Journal of Organic Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 135 KB

english, 1996

32

An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model

Tu, Chengjian, Li, Jun, Bu, Yahao, Hangauer, David, Qu, Jun

Journal:

Journal of Proteomics

Année:

2012

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2012

33

Modeling the Mechanism of Peptide Cleavage by Thermolysin

DAVID G. HANGAUER, PETER GUND, JOSEPH D. ANDOSE, BRUCE L. BUSH, EUGENE M. FLUDER, EUGENE F. McINTYRE, GRAHAM M. SMITH

Journal:

Annals of the New York Academy of Sciences

Année:

1985

Langue:

english

Fichier:

PDF, 787 KB

english, 1985

34

Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells

Saperstein, Richard, Vicario, Pasquale P., Strout, H. Vincent, Brady, Edward, Slater, Eve E., Greenlee, William J., Ondeyka, Debra L., Patchett, Arthur A., Hangauer, David G.

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 948 KB

english, 1989

35

A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies

Aung Naing, Roger Cohen, Grace K. Dy, David S. Hong, Lyn Dyster, David G. Hangauer, Rudolf Kwan, Gerald Fetterly, Razelle Kurzrock, Alex A. Adjei…show all 10hide

Journal:

Investigational New Drugs

Année:

2013

Langue:

english

Fichier:

PDF, 144 KB

english, 2013

36

Total synthesis of pseudoguaianolides: (.+-.)-aromaticin and (.+-.)-aromatin

Lansbury, Peter T., Hangauer, David G., Vacca, Joseph P.

Journal:

Journal of the American Chemical Society

Année:

1980

Langue:

english

Fichier:

PDF, 298 KB

english, 1980

37

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

Hangauer, David G., Monzingo, Arthur F., Matthews, Brian W.

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 2.54 MB

english, 1984

38

Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src

Nair, Shrikumar A., Kim, Moon H., Warren, Stephen D., Choi, Sun, Songyang, Zhou, Cantley, Lewis C., Hangauer, David G.

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1995

39

Correction to Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC

Barb, Adam W., Leavy, Tanya M., Robins, Lori I., Guan, Ziqiang, Six, David A., Zhou, Pei, Hangauer, Matthew J., Bertozzi, Carolyn R., Raetz, Christian

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 558 KB

english, 2009

40

Synthesis of Orthogonally Protected L-Homocysteine and L-2-Amino-4-phosphonobutanoic Acid from L-Homoserine

Nair, Shrikumar A., Lee, Bongyong, Hangauer, David G.

Journal:

Année:

1995

Fichier:

PDF, 499 KB

1995

41

AKT inactivation causes persistent drug tolerance to EGFR inhibitors

Tetsu, Osamu, Phuchareon, Janyaporn, Eisele, David W., Hangauer, Matthew J., McCormick, Frank

Journal:

Pharmacological Research

Année:

2015

Langue:

english

Fichier:

PDF, 793 KB

english, 2015

42

Drug Resistance to EGFR Inhibitors in Lung Cancer

Tetsu, Osamu, Hangauer, Matthew J., Phuchareon, Janyaporn, Eisele, David W., McCormick, Frank

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 899 KB

english, 2016

43

Zerlegung des hydrophoben Effekts auf molekularer Ebene: Die Rolle von Wasser, Enthalpie und Entropie bei der Ligandenbindung an Thermolysin

Biela, Adam, Nasief, Nader N., Betz, Michael, Heine, Andreas, Hangauer, David, Klebe, Gerhard

Journal:

Angewandte Chemie

Année:

2013

Langue:

german

Fichier:

PDF, 1.16 MB

german, 2013

44

Ion Current-based Proteomic Profiling in Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation

Tu, Chengjian, Bu, Yahao, Vujcic, Marija, Shen, Shichen, Li, Jun, Qu, Miao, Hangauer, David G., Clements, James L., Qu, Jun

Journal:

Journal of Proteome Research

Année:

2016

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2016

45

Dual Src Kinase/Pretubulin Inhibitor, KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen Through ERα Re-expression

Anbalagan, Muralidharan, Sheng, Mei, Fleischer, Brian, Zhang, Yifang, Gao, Yuanjun, Hoang, Van T, Matossian, Margarite D., Burks, Hope E, Burow, Matthew E, Collins-Burow, Bridgette M, Hangauer, David,

Journal:

Molecular Cancer Research

Année:

2017

Langue:

english

Fichier:

PDF, 8.70 MB

english, 2017

46

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

Smolinski, Michael P., Bu, Yahao, Clements, James, Gelman, Irwin H, Hegab, Taher, Cutler, David L, Fang, Jane W. S., Fetterly, Gerald, Kwan, Rudolf, Barnett, Allen, Lau, Johnson Y. N., Hangauer, David

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2018

47

KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma

Ciesielski, Michael J., Bu, Yahao, Munich, Stephan A., Teegarden, Paola, Smolinski, Michael P., Clements, James L., Lau, Johnson Y. N., Hangauer, David G., Fenstermaker, Robert A.

Journal:

Journal of Neuro-Oncology

Année:

2018

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2018